Helping the 50g, Prime or Nspire?

[Dave Britten]

I can't speak for the N-Spire, but I will say that the programming environment and capabilities of the TI-89, TI-92, and Voyage 200 are excellent, even if they're all rather poor choices for daily number crunchers for various reasons (the 89 keyboard layout is terrible, and the 92 and 200 are enormous).

I'd suggest finding a TI-89 or 92 emulator and trying it out a bit to see if it would meet your needs. I suspect it's not any better than its competitors at handling very large data sets, though.

You might also consider using Python, possibly running on some portable or handheld device (Android tablet, PocketCHIP, etc.). It seems to be a pretty popular choice for math and data science programming.