(EL512) Pharmacokinetic simulations

02232020, 11:41 AM
Post: #1




(EL512) Pharmacokinetic simulations
An excerpt from Pharmacokinetic simulations with handheld programmable calculators, Division of Clinical Pharmacokinetics, College of Pharmacy, University of Florida, pgs. 1213, JAN 1985
"We have recently taken an interest in teaching principles of simulation exploiting the small, programmable calculators commonly possessed by our students. The calculators concerned are typified by the EL512 (Sharp) … as these usually have … user accessible memories … programming step capability … Our interest is in learning through simulation, and we present here details of a group of programs which provide serial solutions to some representative equations. It is our intention that these programs should be used as models by other investigators interested in analogous problems. The first program (Table I) simulates one compartment kinetics … The program gives a series of solutions of the equation for onehour time intervals." The reader is invited to study these programs with a view to enhancing his or her own ability" BEST! SliseRule 

02292020, 06:50 AM
Post: #2




RE: (EL512) Pharmacokinetic simulations
Thank you, SlideRule! Now what we need is a program that does twocompartment models  pharmacokinetics is not always straightforward as the drug will often be subject to firstpass metabolism and other effects. But that's a digression  these are the sorts of things that ought to go very well in the Prime  one of these days I'll make the time to figure out how to do that....


02292020, 12:27 PM
(This post was last modified: 02292020 03:58 PM by SlideRule.)
Post: #3




RE: (EL512) Pharmacokinetic simulations
(02292020 06:50 AM)JimP Wrote: … need is a program that does twocompartment models  pharmacokinetics is not always straightforward … Perhaps this thread, (TI59) Pharmacokinetic Program, or this thread, (TI59) Pharmacokinetic Analysis & Calculations, in this forum, will suffice? BEST! SlideRule 

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